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New Study Reveals The Truth Behind LDL & Heart Disease — Whalespan

Content›Video›New Study Reveals The Truth …

New Study Reveals The Truth Behind LDL & Heart Disease

Paul Saladino13m · 2024-08-15

Claims Made

22

Claims Supported

9

Support Rate

41%

Support rate

9 of 22 claims supported

9 supported13 partial / not

Claims from this content

20

✓Well SupportedMetabolic health determines the atherogenicity of one's lipid profile.✓Well SupportedIn metabolically healthy individuals, LDL levels are not consistently related to incident cardiovascular disease.✕Not SupportedFocusing solely on smashing LDL levels with drugs is a flawed model for treating heart disease.✕Not SupportedAchieving LDL levels of 20-30 mg/dL would likely lead to significant health problems.Partially Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

Some individuals with very high ldl do not have high plaque burdens or increased cardiovascular risk.

◐Partially SupportedPreliminary results suggest that lean mass hyper-responders on low-carb/ketogenic diets with high LDLs may have less atherosclerosis than expected.

◐Partially SupportedEliminating inflammatory signaling pathways or adjusting receptors with antibodies can eliminate atherosclerosis in animal models.

◐Partially SupportedRegression of coronary artery calcium scores has been observed in individuals with high LDLs, particularly those on ketogenic or carnivore diets.

◐Partially Supported45% of asymptomatic heterozygous familial hypercholesterolemia patients have a CAC score of zero despite an average on-treatment LDL-C of 158 mg/dL.

◐Partially SupportedA study by Dave Feldman and Matthew Budoff examined atherosclerosis progression in individuals with elevated LDL compared to those without.

◐Partially SupportedHigh LDL cholesterol may be less concerning for lipid-lowering therapy if a person has a zero Calcium Score (CAC).

◐Partially SupportedMendelian randomization studies comparing familial hypercholesterolemia patients to lean mass hyperresponders may misrepresent the LDL-atherosclerosis link.

◐Partially SupportedApolipoprotein B (apoB) and LDL levels do not always correlate with atherosclerosis, especially in metabolically healthy individuals.

◐Partially SupportedIndividuals with monogenic familial hypercholesterolemia have high LDL levels coupled with an immune system that promotes more avid uptake of LDL by macrophages in the vessel wall.

◐Partially SupportedPlaque burden is the most important factor in cardiovascular disease risk, rather than solely LDL-C levels.

◐Partially SupportedIn Dave Feldman's study, the incidence of cardiovascular disease was similar in individuals with average LDL levels and those with significantly elevated LDL levels who were lean mass hyperresponders.

◐Partially SupportedLDL particles are modified by metabolic dysfunction, inflammatory signaling, and oxidative stress, which can trigger immune responses leading to plaque formation.

✕Not SupportedAggressively lowering LDL-C to below 30 mg/dL with drugs is a crude approach to treating heart disease.

◐Partially SupportedCardiovascular disease development requires multiple contributing factors, not just high LDL.

✕Not SupportedMaking extreme treatment decisions for heart disease based solely on LDL values without understanding underlying mechanisms is a major problem.