The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
many of the exact same metrics that i would sub stratify ldl versus cardiovascular disease comparisons by just like i showed you with framingham data when you introduce one metric that suggests there is metabolic health or unhealth you see massive differences in the risk of cardiovascular disease by ldl
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if we look at ldl and we only look at studies connecting levels of ldl with incidence of cardiovascular disease without any stratification for insulin resistance or metabolic health and or dysfunction then we will see a correlation between rising levels of ldl and levels of heart disease
in humans that are metabolically healthy by a fasting insulin or by HDL triglyceride Ratio or by CAC scores which is a coronary artery calcium score of zero we don't see any real consistent sort of relationship between LDL levels and incident cardiovascular disease
in humans that are metabolically healthy by a fasting insulin or by HDL the triglyceride Ratio or by CAC scores which is a coronary artery calcium score of zero we don't see any real consistent sort of relationship between LDL levels and incident cardiovascular disease