Paul Saladino· MD
what's oxidizing in LDL linoleic acid it's linoleic acid that's creating this fragile intermediate that's the Tinder in our body
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what's oxidizing in LDL linoleic acid it's linoleic acid that's creating this fragile intermediate that's the Tinder in our body
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endothal cells oxidized LDL forming linolic acid hydroperoxides so when you're getting these oxidized LDL it's usually from linolic acid hydrop peroxides or oxidized linolic acid linolic acid is the most abundant fatty acid in LDL is an extremely vulnerable to oxidation being one of the very first fatty acids to oxidize so we know LDL is a polyunsaturated fat and can readily peroxidize under being exposed to fires which we're seeing in the metabolic dysfunction they say a meta analysis of randomized control trials in humans found that when saturated fats plus trans fat is replaced with omega-6 fat high in linolic acid there is an increased RI an increase in all cause mortality es schic heart disease and Mortal es schic heart disease mortality and cardiovascular mortality and then the last one I'll read here is that the oxidation of of lenol a and LDL leads to conjugated Dianes which can cently bind to apob alterating its structure creating oxidized LDL oxidized LDL is no longer recognized by the LDL receptor on the liver but scavenger receptors on macras causing monoy infiltration into the subendothelium fob cell formation and eventually atherosclerosis
the oxidation of of linoleic acid LDL leads to conjugated dions which can conveyently bind to apo B altering its structure creating oxidized LDL. Oxidized LDL is no longer recognized by the LDL receptor on the liver but scavenger receptors on macrofasages causing monocy infiltration into the subendothelium foam cell formation and eventually atherosclerosis.
When LDL is oxidized, it's more likely to get picked up by a macroofage in the arterial wall. Thus begins the fatty streak in the arterial wall and the beginning of aththerosclerosis.