LPS binding to apoB protein on LDL particles can prevent LDL recycling by the liver and lead to it lodging in arterial walls.

“And so it gets lodged into the arterial wall and because there's an LPS bound to this you know small dense LDL particle macrofasages which are as you mentioned it's like the first line of defense against something like a bacterial invader right it comes and chews it up right gets rid of the problem so macrofasages come in because they're seeing this signal of LPS and think it's a foreign invader when it's actually just a small dense LDL particle bound to LPS that came from the gut tries to engulf it but it can't because it's not bacteria and you get the macrofase stuck to that >> lipoprotein LPS you know complex and you get the formation of a foam cell.”

“the lipoproteins you probably heard of small dense LDL right like that's a very dangerous type of LDL article and that's one that's kind of been donating along getting rid of tro triglycerides and um whatever if you think about a train with cargo it's donating the you know dropping off the cargo and so um when it's time to get recycled back into the liver what do you know the apo proteins obscured by that LPS and it's not recycled and so it gets lodged into the arterial wall and because there's an LPS bound to this you know small dense LDL particle macrofasages which are as you mentioned it's like the first line of defense against something like a bacterial invader right it comes and chews it up right gets rid of the problem so macrofasages come in because they're seeing this signal of LPS and think it's a foreign invader when it's actually just a small dense LDL particle bound to LPS that came from the gut tries to engulf”

“And the ability of LPS to stick to the VLDL means that some of that LPS remains on the particle as it gets smaller and smaller. And if that particle isn't being cleared rapidly, the LPS will be circulating even longer, and it may be part of the whole process by which this contributes to atherosclerosis.”

“But LPS is obscuring that apo and so it does not get recycled and so it stays around in circulation longer. And what happens is as it stays around it's delivering triglycerides. What lipoproteins are doing is they're delivering triglycerides and cholesterol mostly triglycerides fatty acids to your other cells and for repair. You need them for repair and things. But um now this LDL particle can't go back to the liver. It's got to stick around longer. It's it's smaller in size. is it becomes what's called a small dense LDL particle”

“Um part of the adaptive response here is that we start to increase our lipoprotein production. we make more VLDLDL and LDL and that binds to LPS and sequesters it and prevents it from, you know, actually causing a lot of harm.”