Andrew Huberman· PhD
And for all intents and purposes, because the IDLs are so short-lived, that's basically the sum of your LDL cholesterol, your VLDL cholesterol, and your HDL cholesterol.
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
And for all intents and purposes, because the IDLs are so short-lived, that's basically the sum of your LDL cholesterol, your VLDL cholesterol, and your HDL cholesterol.
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So when people say my LDL is high, or my LDL is 100, what are they saying? They're saying the cholesterol concentration of my LDL particles is a hundred milligrams per deciliter.
so when you're looking at your blood test what you're seeing is the cholesterol concentration within the various particle so when it says total cholesterol it says well if you break apart the HDL particle and the LDL particle and the v LDL particle and if you can find it the IDL particle how much total cholesterol do you have and that's a number call it 200 milligrams per deciliter okay when it says ldl-c is 120 milligrams per deciliter that means if you break apart the LDL cholesterol that's the concentration of cholesterol contained within them etc
total cholesterol would be the laboratory has separated all your lipo proteins from the serum and their take how much cholesterol is in this serum tube so where would that cholesterol be that they're analyzing well it would be found in if there were any chylomicrons there that were hanging around or maybe they didn't fast some of it would be called a micron cholesterol some would certainly be V LDL cholesterol a lesser amount because there's just so many so fewer of them would be intermediate density cholesterol particles and the would be in either LDL particles low-density lipoproteins or the high-density lipoproteins
when we measure the cholesterol in the blood the total cholesterol is the cholesterol in the vldl particle the ldl particle and the hdl particle
the non-hdl part cholesterol is the mass of cholesterol in vldl particles and ldl particles