Tangier disease is associated with enlarged tonsils, spleen, and liver, and potentially neurological issues and increased atherosclerotic cardiovascular disease risk.

“this disorder which we can talk about the history it's a fascinating history it's called Tangier disease it's named for a small flat bizarre island in the middle of the Chesapeake Bay where the first patient was discovered this disorder is primarily associated with accumulation of cholesterol in macrophages throughout the body so tonsils spleen places where there are a lot of macrophages the cholesterol really builds up and they have huge sort of orange colored tonsils they have big spleens that sometimes rupture they have big livers because there are a lot of macrophages and macrophage-like cells in the liver and they also have some neurologic type issues especially neuropathy which maybe we'll leave to later when we start talking about HDL in its relationship to the nervous system they may or may not have some increased risk of atherosclerotic cardiovascular disease”