Animal models, particularly with species like hamsters or guinea pigs that have lipid systems comparable to humans and possess Lp(a), are needed to study the long-term effects of modified LDL particles.

“i really feel paul like there's a lot of opportunity for things like animal models where you just let them live out a life a true you know honest to goodness life with potential modified ldl particles in the way that we think would be beneficial as opposed to these very super short experiments where you don't actually get to see it the one catch is it's hard to do with ribbons because rodents have a very different lipid system than we do you have to do it with something like you know hamsters or um i think it's guinea pigs that are at least somewhat comparable to us and also have like say lp little a”