Apolipoprotein B (ApoB) is a meaningful biomarker for cardiovascular risk.

“they're not doing things like the eight will be the a ratio which is a linear correlation it's like as Abel the April 8 goes up so this card it's a heart attack risk and that is that is infinitely more predictive than then when you look at total cholesterol or total LDL HDL”

“if you do this diet biomarkers XY and Z and maybe even your waistline looks better but april-b olio P doesn't matter in them every single thing that's ever been done genetically or properly done clinical trial shows it does matter and an individual can I say yes it matters in you it does not no but if I want to follow the bulk of the data it matters over time”

“now that hasn't moved the american guidelines but on the evidence side uh there there are there are a handful of studies that show that non-hdl cholesterol may be equal to b there are more studies that actually show apob is better but we developed an a way of looking at it called discordance analysis to identify people who had a high non-hdl cholesterol which is the total cholesterol in the apob particles but a low apob total number of particles versus low non-hdl high apob so if you're a cholesterol maven you got a bet on the one with a high non hdl if you're an apob aficionado you bet on the one with the lower non-hdl higher a b they all show its apo b now is the argument going”

“you've got the real Persona dramatis which is why it's surprising that HDL didn't at least at the first order demonstrate causality because there's no doubt that phenotypically the high triglyceride low HDL phenotype is so associated with metabolic syndrome but it makes up two of the five criteria that's an incomplete description that's like you describing your self as six feet tall I wish and not giving your weight and letting me guess your BMI you cannot characterize any phenotype without the apob”

“A lot of Clips will focus on why I think APO B is a superior lipid metric to LDL cholesterol or even non-hdl cholesterol when trying to predict risk”

“I think that one could could could argue that that apob is not sufficient but is necessary which is how I feel and still take it very seriously”

“so I'm not sure what the other markers would be outside of you wait long enough you're going to get some Imaging thing that's positive or uh do we just start respecting APO B and that's basically where the lipid world is going”

“apob which is the marker of particle Concentra is going up and of course that's the metric that matters”

“is all of the risk of everything you just discuss captured in the apob marker yes”

“there's an even better way to predict risk than just saying how much cholesterol is contained within the low density lipoproteins a better way to predict risk is to add up the concentration of all the apob particles so that number apob measured in milligrams per deciliter is the concentration of the entire burden of particles that are capable of undergoing something that I'm sure we'll talk about which is the initiation and progression of atherosclerosis”