Plaque buildup in arteries may involve blood flow creating 'wounding' on arterial walls, with plaque acting as a scab.

“there's a textbook called the physics of cerebrovascular diseases biophysical mechanisms of development diagnosis and therapy okay and it gets into um the like the the physics of plaque buildup in your arteries as opposed to it just being a chemical conversation within like food and cholesterol and fat and LDL and HDL also the the effect of blood circulating through your vascular system your arteries and the when it wraps around certain angles it will bump into the sides of the walls creating like wounding yep and then that plaque is almost like a scab yes so this is a different perspective than I think is common to anyone”