David Sinclair· PhD
Niacin (vitamin B3) can provide modest reductions in Lp(a) but studies have failed to show that niacin reduces heart disease risk.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Niacin (vitamin B3) can provide modest reductions in Lp(a) but studies have failed to show that niacin reduces heart disease risk.
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
You know, people want to use niacin. Maybe niacin has a 10%, maybe 20% reduction in it, but you really got to get it to be like 90% more reduction to really have a clinical benefit.