Peter Attia· MD
if you have smaller leo's you need a ton of them to carry whatever your lipid load is so you got a super high LDL particle concentration and that's more related to its pathology per say than the size
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
if you have smaller leo's you need a ton of them to carry whatever your lipid load is so you got a super high LDL particle concentration and that's more related to its pathology per say than the size
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the small dense particles essentially are file marking inflammation so the LDL particle being small and dense means that there's inflammation going on
And that's one reason we think that these particles are less capable of being removed from the blood by the liver. There are other features of these particles that contribute to that, including changes in other proteins that may inhibit receptor-mediated uptake of the smaller LDL.
well he's also shown him and collaborate his collaborators and colleagues that you know inflammation can you know can basically you know cause a larger buoyant ldl to form a small dents