Andrew Huberman· PhD
because we believe that the system is regulated by estrogen so the decline in estrogen starting around age 40 43 is kind of the average seems to be the driver behind cerebral hypom metabolism
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
because we believe that the system is regulated by estrogen so the decline in estrogen starting around age 40 43 is kind of the average seems to be the driver behind cerebral hypom metabolism
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starting around age 40, there is this massive change in cerebral metabolism so you can do fdg pet scans you can look at glucose uptake and there's about on average a 20% decline from Prem menopause you know up to like age 35 to per menopause to postmenopause