Mild hypothermia protects neural tissue by quieting electrical activity, reducing metabolic activity, blocking excitatory amino acid release, inhibiting calcium influx, and reducing inflammation.

“another method of protecting the brain was tried called mild hypothermia and that uh was a process of reducing the brain temperature and body temperature just a few degrees from 37° centigrade to 33 and we were one of the first to to show um that that was protective even after the stroke in animals”

“in animal models and again this is something that I've I've published extensively on hypothermia is Magic for acute brain injuries right if you can decrease core temperature by 3 to 4 degrees cius for you know three you know 24 hours to 72 hours after the injury you you get a significant reduction in in brain injury in one specific scenario and that's acute um acute uh brain injury in babies that have some kind of issue around birth therapeutic hypothermia so cooling to 33.5 degre Celsius core temperature for three days is the standard of care it was brought into the resuscitation guidelines in 2010”