Nutritional ketosis can alter brain energy metabolism and neuropharmacology, including shifting the GABA-to-glutamate ratio in favor of higher GABA.

“It's thought that, and there's different reasons for that. There's glutamic acid decarboxylase is an enzyme. That's part of it. I think there's about 20 or more things going on if you look at all the signaling pathways [crosstalk 00:39:37] actually what happens, yeah, with metabolism, but I think a key player in that is an elevation of GABA to glutamate. And we need glutamate to make GABA, right, but the enzyme is elevated and the pathways are shift in favor of more glutamate to GABA, which has a stabilizing effect on your cell membrane and neural interactivity, in general.”