Andrew Huberman· PhD
I think that one of the key cell types that's going to be important for your hypothesis um linking inflammation to synaptic plasticity is going to be a cell called a micral cell and micral cells are non neuronal cells in the brain they're motile they can crawl around they have long processes and they can gobble things up they can literally sort of chew away way and digest bits of the extracellular scaffolding that surrounds neurons and synapses and thereby renders them plastic they can uh destroy synapses and there is a lot of indication that certain disease States may involve over exuberant microa pruning synapses to a degree that they shouldn't and we know that microa are chock full of cyto kind receptors and so are responsive to inflammatory signals