Estrogen receptor density in the brain increases with age up to 65 and correlates with brain fog and irritability.

“I This is crazy research. Okay, I don't know if you've had Lisa Mossone on, but here's this researcher from Cornell, neuroscience researcher, who says, "Hey, I want to study Alzheimer's. I want to do this. This is just in the last couple years." And she goes to her lab manager and says, "Okay, what's the assay for estradiol in the brain? I need to look at estradiol receptors in the brain." And the people at Cornell was like, "That doesn't exist." She's like, "What do you mean that doesn't exist?" She's like, "How can we not look at estrogen receptors in the brain?" So she gets um Maria Shrivever to give her a giant amount of money who gives her a huge amount of money. So she now develops this assay. This is only within the last couple of years. She just published in nature very early findings that what would you expect? Right? Your body is efficient. It's not going to do things it doesn't need to do. So the hypothesis was that as menopause gets later and later the estrogen receptors in your brain are going to downregulate. Why have receptors around when there's no estrogen to feed the brain? What did she find? the exact opposite, right? That actually even up to 65. She stopped looking past 65 cuz she's like, "There's no way that's going to matter, the increase in receptor density the older you get and it correlates to brain fog and irritability, you know, sort of correlates to all these symptoms."”

“It's it's one of the most common symptoms and all women start going to doctors in their 40s like like doctors you're I know you're listening and you get so many people and every day you say, "Oh, it's probably hormonal." But you're not giving them the solution. You're just telling them it's not cancer. So the neurologists are seeing all these patients to rule out um you know a cognitive decline or all these other issues, but really it's that brain fog because your brain is filled with estrogen receptors.”

“The increase in receptor density the older you get and it correlates to brain fog and irritability, you know, sort of correlates to all these symptoms. My reading of that was estrogen is so important in the brain that it has to upregulate the receptors as the estrogen level goes down and down and down.”