Cerebrolysin, used for post-stroke and post-TBI, can cause a temporary, significant mood shift to a 'dark place' in some individuals.

“cerebral license has been used for decades in the setting of you know poststroke um post traumatic brain injury the trouble with it again I've observed with people they get cerebral license we're talking about IV you can also use it subq is they will have a day or two where they feel really down and out like it's like their mood shifts to like this dark place um scary yeah and they come out of it um but most people don't like that feeling and so we just we stopped using it mostly yeah for that reason”