The brain's dopamine reward circuitry is complex and modified by prefrontal inputs, memory systems, and context.

“Because on the one hand, you have done a fantastic job over the last few years in your podcast of making complex subjects accessible to a lay audience and get them to be thinking about how our modern view of how the brain works could be used to enhance health, could enhance mental well being. But as neuroscientists, academic neuroscientists ourselves, we know, you know, you are oversimplifying things, and the actual functioning of a system like the dopamine reward circuitry, as you just eloquently pointed out, is so much more complex.”