Functional disconnection or deactivation in the posterior cingulate cortex can lead to memory deficits similar to those seen in the initial stages of dementia.

“so when you functionally generate a region in the brain eventually that leads to atrophy from the region that is receiving the stimulus he was receiving that just like happens when you denigrate a muscle in the periphery there is a trophic action and action that that region survives because it's being stimulated by the other one so people have missed when you study pathology you don't study these functional changes and you don't look at the system as a network of pathways or influence functionality you're seeing the end result what has happened after all these processes are taking place over the years so by doing that you cannot in fear this all the phenomena if you take an animal like a mouse and you just take out the it's the posterior cingulate the procedures if you lesion that in a rat or a mouse acutely which is not the same as what's presumably happening in this diseased state what is the immediate phenotype of that animal or behavior well you don't have to live in it you can functionally deactivate which is more similar to what it's actually happening in Alzheimer's is not that this region is damaged structurally right it's just functionally not allowing the conduit yeah it's a signaling affecting that network that is providing the main input to the hippocampal formation you get the same kind of memory deficits there are characteristics of the initial stages of dementia”