Muscle wasting in the calf can indicate degeneration in upper motor neuron pathways or other brain areas.

“When I see someone getting out of their car and and walking up to the clinic door and I can see the muscle wasting on their calf and they'll say oh I have to get out my EMG uh nerve conduction velocity scores here I said are you kidding me you telling me the doc needed to do an EMG conduction velocity and all they had to do was look at your leg we know exactly the nerve roots that are deficit because I know exactly what serves those muscles that have wasted”