Andrew Huberman· PhD
The no-go pathway, the pathway in the basal ganglia, and cortex that suppresses action, involves dopamine binding to this other receptor called the D2 receptor.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
The no-go pathway, the pathway in the basal ganglia, and cortex that suppresses action, involves dopamine binding to this other receptor called the D2 receptor.
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The basal ganglia has one set of connections to the cortex, and the cortex back to the basal ganglia that facilitates go. It facilitates action. And the molecule, the neuromodulator dopamine, triggers the activation of go. It tends to make us want to do more things. It tends to make us bias toward action.