Brain areas involved in physical activities like jumping, landing, throwing, navigating uneven surfaces, and dealing with unfamiliarity may be the first to atrophy in humans.

“And perhaps, and someone should look at this, I think perhaps the areas of the brain that atrophy first, the neural pathways that atrophy first in everybody, we're not talking about Alzheimer's necessarily, are the areas involved with jumping, landing, throwing navigating uh uneven surfaces, um, lack of familiarity, you know, as and it could be that the deterioration of those pathways sets in motion a cascade of of things that cause the loss of neurons in other areas and then like so many things you know it tends to then we get like everyone gets demented with age.”