The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
It appears that guanfacine can activate the prefrontal cortical networks in ways that are above their normal Baseline so that's good so improvements in executive function that Orchestra or teacher-like function we talked about before and can increase the efficacy of that output from Locus ceruleus and what that seems to do is increase the coordinated firing of locus ceruleus neurons with prefrontal cortex
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
quanin effects seem to deal with strengthening synaptic Connections in prefrontal circuitry so unlike most of our drugs which are just boosting norepinephrine Andor dopamine and work quickly
so jumping back to Guan facine seems to work slowly so the synaptic strengthening building and it seems to be the nor the alpha receptors that are on um neurons that receive glutamate is our primary input the Alpha 2 receptor is modulating how glutamate is actually working