Neural plasticity and rewiring of brain circuitry occur when the brain's chemical milieu changes, often involving adrenaline.

“However, alertness alone is not sufficient. As we would say, it's necessary but not sufficient for neuroplasticity.”

“Epinephrine is released from a region in the brainstem called locus coeruleus... essentially waking up the entire brain and that's because the way that epinephrin works by binding particular receptors is to increase the likelihood that neurons will be active. So no alertness, no neuroplasticity.”

“what sets the context for massive change in our neural circuitry is when there's a lot of adrenaline in the body sorry folks it's true adrenaline also called epinephrine and nor epinephrine released in the brain”