The brain has a high density of hormone receptors, particularly estrogen and androgen receptors, which directly influence neuromodulators like serotonin, dopamine, and GABA.

“I think most people don't realize how rich the brain and rest of the nervous system are with hormone receptors in particular I estrogen receptors and as you mentioned testosterone receptors as well Androgen receptors um and the often direct relationship between estrogen and the neuromodulators such as serotonin dopamine epinephrine aceto Gaba for for um progesterone”