Multiple factors likely contribute to both normal age-related cognitive decline and pathological cognitive decline leading to dementia.

“if you then translate that to what we might call some kind of pathological cognitive decline which would then lead into Frank dementia which is — sort of a long-term loss of significant — cognitive capacity or you know cognitive dysfunction then you might see an accelerated trajectory so there's some period of what we call Mild cognitive impairment which you can diagnose with some standardized cognitive tests and then eventually that will continue into Frank dementia”

“and there are probably multiple things that drive both of those paths”

“if you then transl translate that to what we might call some kind of pathological cognitive decline which would then lead into Frank dementia which is um sort of a longterm loss of significant uh cognitive capacity or you know cognitive dysfunction then you might see an accelerated trajectory so there's some period of what we call Mild cognitive impairment which you can uh diagnose with some standardized cognitive tests and then eventually that will continue into uh Frank dementia”