Hyperactivity of neural circuits in bipolar disorder may transition to hypoactivity over time, possibly due to circuit death.

“Because if you have a situation in which in one disease, let's just, hypothesize here for a second that for instance, in certain forms of schizophrenia, there's elevated dopamine and where we to just reduce the amount of dopamine, that they would receive relief from those schizophrenic symptoms, well, that's all pretty straightforward on the face of it, but in this situation with bipolar disorder, what we're talking about is hyperactivity, too much activity leading to hypoactivity through death of those very circuits.”