Serotonin 2A receptors are highly expressed in the neocortex, including the prefrontal cortex, which is involved in understanding context and regulating behavior.

“Now, the serotonin 2A receptors are located in multiple brain regions. But they have a tremendous amount of expression in the so-called neocortex, the outside of the brain that includes things like our prefrontal cortex, which is involved in understanding context, which behaviors, thoughts, and speech patterns are appropriate for certain circumstances, how to switch context and category switch when you go from playing sports, to hanging out with friends, to being in a professional setting.”