Exercise is a powerful intervention for mitigating cognitive decline, likely mediated by BDNF and increased microvascular function.

“it's not just what it's doing to BDNF. It's not just what it's doing to vascular endothelium. It's not just what it's doing to glucose disposal and insulin signaling and all these things.”

“improved vascular vasculature blood flow and reduced inflammation”

“I think you can make a pretty compelling case that there is no intervention that has shown a larger impact in mitigating cognitive decline than exercise yes and all avenues seem to flow through BDNF and increased micro vascular composure”