Waiting approximately four hours after a hypertrophy workout before cold exposure is theoretically optimal to avoid disrupting protein synthesis signaling.

“Well, in theory, the best answer we could give you would be four hours, because of what we talked about earlier today of going okay. Immediately, you've got the signaling cascade that takes seconds. You've got gene expression that's happening in this rough four hour window. After the genes have gone off and now you're just going through the protein synthesis process, the signal's already there and it's gone back down to baseline. So then reintroducing, or introducing cold here is not going to disrupt that signal. That's a very non-scientifically founded because we don't know, at this point at all.”

“if Del CBC cold exposure is done too soon after a hypertrophy adaptation inducing workout yeah right all the sorts of things we've been talking about that the hypertrophy response can be blunted reduced or eliminated is that true”

“Cold exposure blocks that signal remember adaptation comes from stress you've put in a stressin now you've blocked that stress you've literally block the signal that tells your body come back and grow larger size”

“um, he was saying, you know might want to, you know, wait 24 hours.”