Cold adaptation increases mitochondrial production in adipose tissue, regulated by norepinephrine and PGC1-alpha, for heat generation.

“And another type of adaptation that occurs is you actually produce more mitochondria in your atapost tissue. And um and that actually happens also regulated by norepinephrine or noradrenaline through a protein called PGC1 alpha. And what that protein does is it makes more mitochondria in your atapost cell. So per atapost cell you're getting more mitochondria. It's a beautiful way to basically make more heat when you're it's it's one of those things where it's like it's your body's going, "Okay, I'm going to be exposed to this cold next time. How can I make sure I don't die? Oh, I can have more mitochondria and I'm going to make more heat." And so you're making more mitochondria in your atapost tissue.”

“this is all regulated by norepinephrine so that's very interesting because I just talked about norepinephrine and how it regulates mood Focus attention me makes you feel good uh helps with anxiety but it also appears to regulate this process because if you block the in the brain's ability to respond to neurop nephrine then mitochondrial biogenesis does not occur upon cold exposure in adapost tissue so that nephrine is very important for that”

“another mechanism that we're that we use to generate heat is also related to norrine and that has to do with increasing mitochondrial biogenesis in your adapost tissue and in your muscle tissue”

“but there's a catch not all fat can do this equally this type of thermogenesis is mostly a quality of a type of fat known as brown fat ... we've since found it in adults as well particularly falling cold exposure and that is because other types of fat can take on thermogenic characteristics of brown fat a process that also involves mitochondrial biogenesis that is regulated by you guessed it the release of norepinephrine in response to cold”

“what's happening is when you're get getting yourself exposed to the cold, norepinephrine goes up, that increases a protein called PGC1 alpha, which then increases mitochondrial content in muscle tissue.”

“Muscle also is increased. So, um, this there there's been a few studies that have shown again, um, what's happening is when you're get getting yourself exposed to the cold, norepinephrine goes up, that increases a protein called PGC1”

“Well, the norepinephrine is increasing a protein called UCP1, which then signals to your atapost tissue to make more mitochondria.”