Cold exposure in mice at 4°C for 45 minutes activates cold shock proteins, including RBM3 in neurons, which promotes the regrowth of lost synapses.

“But cold more recently I became interested because there was a paper that was published in Nature last January, where researchers took mice and exposed them to about 4 degrees Celsius for 45 minutes, cased their core body temperature, so unlike Wim, their core body temperature dropped from, you know, 98.6 to about 65 degrees Fahrenheit, so very in hypothermia almost but what was very interesting is that the cold shock…there's a whole class of proteins called cold shock proteins that are activated by the cold and one of them specifically is in the brain and at the dendritic spine region of neurons, and it increases dramatically in the cold.”