The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
what you've got is this highly correlated and poorly correlated reduction in both glutathione which is the master antioxidant that's seen as the head of the tree but also there's a reduction in the uric acid concentration suggesting that the uric acid is acting as a an electron donor in that cascade of events
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
have higher levels of glutathione because they're exposing themselves to an oxidative stress frequently they have hormesis and they illustrate that hormetic effect or they illustrate the oxidative stress specifically when these people swim so you can look at the graphs in there and see that this is very different than something like sulforaphane which also activates the nrf2 system
they check glutathione levels before and after a cold water swim and they see glutathione levels go down specifically they see reduced glutathione levels go down and oxidized glutathione levels go up meaning that they are oxidizing glutathione and they are they are having oxidative stress meaning glutathione is doing its job and so what they're seeing in the swimmers is that overall they have higher levels of glutathione because they're exposing themselves to an oxidative stress frequently they have hormesis
what they found was that the cold water swimmers in Berlin who were swimming for an hour a day or multiple times a week in the winter had levels of glutathione that were higher than regular people meaning they had had hormesis environmental hormesis
they show that both uric acid uric acid declines first and then glutathione declines well glutathione and uric acid both decline I'm trying to think if there's a sequentiality there but what they're saying is that number one this is an environmental hormetic it's creating oxidative stress when you go in the coal then it's creating and you'll see you're seeing that because glutathione is being used up but also that uric acid is serving as an intermediate and potentially either regenerating glutathione or doing some of the antioxidant work itself
so you see that glutathione levels will decrease both oxidized and reduced uh with acute cold exposure and then they go up the next day and so that's quite interesting that glutathione is being consumed which is the fact that cold exposure causes oxidative stress heat exposure causes oxidative stress your body is going to consume glutathione and uric acid goes down and then bumps up the next day
could both uric acid and glutathione be antioxidant mechanisms b mechanisms by which the body is managing reactive oxygen species which occur in things like cold and hot
so you see that glutathion levels will decrease both oxidized and reduced uh with acute cold exposure and then they go up the next day and so that's quite interesting that um glutathione is being consumed which is the fact that cold exposure causes oxidative stress heat exposure causes oxidative stress your body is going to consume glutathione and uric acid goes down and then bumps up the next day
there's a study that I've referenced many times in the past that looks at both uric acid and glutathione levels in cold water swimmers and this one is very interesting because both uric acid and glutathione levels drop during short-term whole body cold exposure