Andrew Huberman· PhD
There have been some papers to show that cold water immersion can actually enhance mitochondrial biogenesis. And actually, even for endurance stuff it's been shown to cause improvement in endurance adaptations, relative to not.
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
There have been some papers to show that cold water immersion can actually enhance mitochondrial biogenesis. And actually, even for endurance stuff it's been shown to cause improvement in endurance adaptations, relative to not.
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And this is regulated, not via norepinephrine, but it is still PGC-1alpha, interestingly, not that anyone else really cares but me, and maybe you do, Andrew. - I'm eating this up. - So PGC-1alpha responds to norepinephrine in adipose tissue to make more mitochondria, but, in muscle tissue, it's unclear what the regulator is. Cold exposure does it.
and studies in both mice and humans have shown that cold water immersion increases levels of pgc-1 alpha in skeletal muscle pgc1 alpha is a protein that regulates mitochondrial biogenesis the production of new healthy young mitochondria