Environmental hormesis, such as sun exposure, exercise, cold, and heat, activates Nrf2 without the negative side effects of exogenous foreign molecules.

“people would argue that plant molecules are necessary for antioxidant defense I would say that is not true that is because we can induce we can get all the oxygen stress we need through exercise cold heat and Sun we don't need plant molecules to have these hormetic events”

“we can get adequate glutathione optimal antioxidant status with living a radical life you know this cold heat you know go jump in a cold lake heat exercise sunlight these are the HAR medics that we need what I believe we don't really need molecular hor medics”

“if we are living a radical life this means hot cold swimming in cold water right exercise Sun may be holding our breath free diving with friends and being safe about it or other environment or medics that our body will be able to manage antioxidant status ideally without the plant molecules we don't need the plant molecules they have side effects that are overall negative I would say and they're redundant they have these collateral effects that are damaging”

“getting in the sun exercise cold heat these don't have the same side effects that sulforaphane and so many of these plant molecules have”

“go do some sprints go in the sun go exercise go sit in the sauna go get in a cold bath and those environmental activities don't have side effects like a plant molecule”

“so so many of these plant molecules are believed to be helpful because they turn on Nrf2 because they are prooxidants they're not antioxidants they're prooxidants well guess what you can get plenty of pro oxidation in your life go do some Sprints go in the sun go exercise go sit in the sa and go get in a cold bath”

“both cold exposure and heat will activate cun genes it will also activate a little bit of oxidative stress oxidative stress increases glutathione because it turns on Nrf2”