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Answering your burning questions! Ask Me Anything (AMA) #3

PS

Paul Saladino1h 12m · 2021-03-02

Support Rate

71%

106 of 149 claims supported

Support rate

106 of 149 claims supported

106 supported43 partial / not

Claims from this content

120

Well SupportedThe Hadza people feed their children meat and fruit and generally do not eat vegetables, leaves, stems, or seeds unless necessary.Partially SupportedIntravenous BPC-157 administration provides a rapid, short-term anti-inflammatory effect, while subcutaneous administration offers a longer-lasting effect.Well SupportedHumans have historically relied on animal foods as the primary source of protein and nutrients.Well SupportedIncluding organ meats in the diet mimics ancestral eating patterns and provides nutrients without plant toxins.Not SupportedSulforaphane may scavenge iodine and act as a goitrogen, with toxic effects.

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

Well Supported

Hunter-gatherer groups prioritize eating organ meats first after a hunt.

Not SupportedSulforaphane is directly toxic to the thyroid gland, inhibiting iodine uptake and thyroid hormone production.

Well SupportedPaul Saladino has a fasting blood sugar of 74mg/dl, low glycemic variability, and clear insulin sensitivity while consuming a few tablespoons of honey daily.

Well SupportedHoney causes a lower elevation in plasma glucose and triglycerides and lowers CRP compared to dextrose and sucrose.

Well SupportedAnecdotes suggest vegan diets can cause hair loss due to deficiencies in bioavailable nutrients from animal foods.

Not SupportedSulforaphane is not considered net beneficial and may be net toxic.

Well SupportedEnvironmental hormesis, such as sun exposure, exercise, cold, and heat, activates Nrf2 without the negative side effects of exogenous foreign molecules.

Well SupportedCold stress can induce oxidative stress in the human body, similar to molecules like sulforaphane.

Well SupportedMeat has been a central part of human evolution and is intuitively perceived as beneficial due to its nutrient richness.

Well SupportedVisceral adipose tissue can be monitored using DEXA scans or MRI to track health progress.

Well SupportedOrgans like liver provide nutrients such as folate, riboflavin, choline, biotin, vitamin A, and copper, which are less represented in muscle meat.

Well SupportedThe microbiome composition of the Hadza gut shows seasonal variation, shifting towards a 'Western gut' profile during the dry season when meat consumption increases.

Well SupportedAn animal-based diet is similar to a carnivore diet but includes some of the least toxic plant foods.

Well SupportedLow-dose, short-duration cold exposure acts as a hormetic stressor, triggering adaptations that protect the body against future, larger stressors.

Well SupportedAn animal-based diet can be affordable, costing less than $15 per day at stores like Walmart or Target.

Well SupportedIn humans, a high linoleic acid diet increases oxidative stress markers and decreases nitric oxide metabolites.

Well SupportedA comprehensive panel for thyroid health should include ferritin or iron testing, vitamin D, B vitamins (like B12), and homocysteine, as these are interconnected.

Not SupportedKale and other garden plant leaves contain defense chemicals and toxins, making them survival food at best for humans.

Not SupportedHoney is not suitable for individuals with type 1 or type 2 diabetes until their glycemia is normalized.

Well SupportedSeed oils, inadequate nutrition, and lack of animal products contributed to chronic disease in ancient Egyptians.

Well SupportedBrushing teeth with honey is a viable alternative to toothpaste and may be healthy for teeth.

Well SupportedDiversity in the gut microbiome is achieved through a diversity of experiences, such as exposure to dirt, sun, and water.

Well SupportedMRI technology visualizing visceral fat can be a game-changer for creating behavioral change by showing individuals how their daily decisions impact their fat levels.

Partially SupportedEnvironmental hormesis, including sunlight, exercise, ketosis, fasting, cold exposure, and heat exposure, can increase glutathione levels.

Partially SupportedCarbohydrates do not cause cavities; the absence of sufficient fat-soluble vitamins is the cause of tooth decay.

Partially SupportedHistorically, Egyptians consumed palm oil and possibly other seed oils, alongside carbohydrates, and exhibited atherosclerosis.

Not SupportedLong-term ketosis from a strict carnivore diet can lead to electrolyte imbalances and energy crashes, suggesting a need to include some carbohydrates.

Partially SupportedTooth decay is controlled by adontoblasts and immune cells in the teeth, which function properly when sufficient fat-soluble vitamins (like K2 and A) are present.

Partially SupportedAn animal-based diet may help more people achieve significant health improvements compared to a strict carnivore diet.

Partially SupportedRaw, organic honey, when consumed in moderate to large amounts, does not trigger Candida overgrowth and has been used as an antifungal against Candida species.

Partially SupportedBread wheat's gluten lectins can disrupt gut tight junctions, causing leaky gut and immune system activation.

Well SupportedSugar from fruit is not bad for humans and should be welcomed into the diet in moderate amounts.

Not SupportedA diet high in linoleic acid decreases nitric oxide metabolites, increases oxidative stress, and causes endothelial dysfunction compared to a high oleic acid diet.

Not SupportedAntifungals and antibacterials generally do not work for gut dysbiosis because they do not address the underlying ecosystem imbalance.

Not SupportedSulforaphane and other plant compounds can impair glutathione recycling, which is a toxic mechanism.

Partially SupportedStem cell therapy was used effectively to treat a runner's knee injury that prevented walking, resulting in no knee problems approximately two years later.

Partially SupportedProtein peptides like thymosin alpha-1 and ipamorelin are used for anti-aging and hormone stimulation.

Partially SupportedThe shift to fatty acid preference in aging humans may be linked to damaged mitochondria, potentially explaining benefits of ketogenic diets for dementia.

Partially SupportedThe food consumed acts as a genetic signal, with meat and organs signaling abundance and success, whereas a gatherer signal may lead to unhealth.

Partially SupportedRestoring the entire microbiome community through lifestyle changes, such as exposure to diverse microorganisms found in nature, is the long-term solution for gut dysbiosis.

Partially SupportedAntimicrobial or herbal treatments may be indicated for specific pathogenic organisms like Entamoeba histolytica or tapeworms, but are generally not effective for dysbiosis or fungal overgrowth.

Partially SupportedHoney is a whole food with beneficial compounds that positively affect the microbiome and cellular function, unlike pure sucrose or high-fructose corn syrup.

Partially SupportedLocal raw honey can be a good source of calories and may help with allergies due to local pollen content.

Partially SupportedCarbohydrates are not inherently enemies, and individuals with diabetes should limit them while understanding that seed oils may be a more significant underlying culprit.

Partially SupportedThymus and alpha-1 peptide treatment significantly reduced mortality in severe COVID-19 patients by restoring lymphocytopenia and reversing exhausted T cells.

Partially SupportedA healthy gut microbiome can be supported by spending time in nature, in the sun, and near bodies of water, filtering water, and consuming some dirt from wilderness sources.

Partially SupportedPeptides like thymus and alpha-1 are preferably obtained from whole foods (organs) rather than synthetic injection or oral supplementation.

Partially SupportedAncient Egyptians likely had problems due to nutrient deficiency and the presence of seed oils, rather than carbohydrates.

Partially SupportedExposure to dirt is a key requirement for human health.

Partially SupportedAncient Egyptians had 21 names for vegetable oils derived from various seeds.

Partially SupportedExtracts from cabbage and acidified Brussels sprouts have shown estrogenic effects on a human breast cancer cell line.

Partially SupportedCalcium is an important dietary component regardless of dietary pattern.

Not SupportedData on the health benefits of antioxidants in humans is generally poor, and they can negatively impact exercise performance and mitochondrial biogenesis.

Partially SupportedHunter-gatherer populations generally exhibit fewer dental caries, bone problems, and parotic hyperostosis compared to agriculturalists.

Partially SupportedMetabolic flexibility allows for greater flexibility in pivoting in and out of states like ketosis.

Partially SupportedSeed oils are a more likely initial trigger of metabolic dysfunction and diabetes than carbohydrates.

Partially SupportedBone matrix, a microcrystalline hydroxyapatite supplement containing calcium, boron, manganese, strontium, and bovine sources, is being released.

Partially SupportedA low-carbohydrate diet and the removal of seed oils are beneficial for individuals with metabolic dysfunction and diabetes.

Partially SupportedThe Nrf2 pathway can be activated by cigarettes, alcohol, lead, mercury, sunlight, cold exposure, and ketosis.

Not SupportedWheat-based carbohydrates are nutritionally deficient and do not lead to good health.

Not SupportedSugars are not the root cause of candida overgrowth, and long-term ketosis may be harmful for humans, leading to candida recurrence when carbohydrates are reintroduced.

Partially SupportedPeople cannot be forced to change their health behaviors; they must be ready for change themselves.

Partially SupportedLong-term ketosis may not work for many humans due to a genetic basis, and individuals should consider including carbohydrates like honey or seasonal fruit.

Partially SupportedKetogenic diets are valuable for individuals with Parkinson's disease and dementia due to their effectiveness in addressing mitochondrial dysfunction.

Partially SupportedThe transition to agriculture caused health problems likely due to nutrient deficiency.

Partially SupportedPlasma s-ICAM1 remained unchanged in linoleic acid and control groups throughout the study.

Partially SupportedAncient Egyptians likely had higher levels of heavy metals due to using sand to grind grains into bread.

Partially SupportedExcess seed oils are a primary driver of genetic changes related to food.

Partially SupportedA high linoleic acid diet can predispose individuals to endothelial dysfunction long-term.

Partially SupportedClinical trials testing the health benefits of dietary antioxidants have reported mixed or negative results, and many studies on the benefits of fruits and vegetables show no benefit.

Partially SupportedDemonstrating the benefits of an animal-based diet through personal example (energy, vigor, strength, libido, sleep, mental clarity) is more effective than telling others about it.

Not SupportedReal carbohydrates like fruit and honey are not inherently problematic for the gut microbiome and can be beneficial.

Not SupportedFiber is not universally beneficial for digestion, and key nutrients from animal foods are not obtainable from plant foods.

Not SupportedObservational epidemiology studies are often flawed and may not have a strong scientific basis.

Not SupportedCarbohydrates do not cause Candida overgrowth in individuals who consume them without experiencing overgrowth.

Partially SupportedPopulations consuming moderate to large amounts of carbohydrates can avoid chronic disease if they obtain sufficient nutrients from animal sources like meat and organs eaten nose-to-tail.

Not SupportedExtrapolation of in vitro data for antioxidants to individual behavior may be misleading due to underestimated physiological relevance of pro-oxidative and other activities.

Partially SupportedWhole foods are important because the body reacts differently to their processing at genetic and epigenetic levels.

Partially SupportedGrass-fed, grass-finished meat is better for the planet and less toxic than regular meat.

Partially SupportedDiets heavily reliant on grains can lead to health problems due to nutrient deficits.

Partially SupportedDrinking filtered wilderness water can provide beneficial molecules for human health.

Partially SupportedHunter-gatherer populations are exposed to dirt through their food and environment.

Partially SupportedEating tubers with dirt on them provides exposure to beneficial soil compounds.

Partially SupportedFat-soluble nutrients found in liver and organs are important.

Partially SupportedDecreased nitric oxide metabolite concentration indicates endothelial dysfunction.

Partially SupportedConsuming organ meats like spleen and bone marrow, in addition to thymus and histamine supplements, can positively impact the immune system.

Not SupportedTerra hydrate, containing humic and fulvic acids, is redundant as these compounds are found in dirt and environmental exposure provides similar benefits.

Not SupportedGoitrin and other isothiocyanates found in brassica vegetables can inhibit iodine uptake by the thyroid and potentially lead to hypothyroidism.

Partially SupportedAchieving health goals requires investment of resources, including time, money, and attention.

Partially SupportedGrains like wheat and corn may act as signals to the body, potentially indicating famine and causing epigenetic changes.

Not SupportedConstant ketosis is not necessary for everyone, and dogma around it can be detrimental, as metabolic flexibility allows the body to function well in or out of ketosis.

Partially SupportedExcess linoleic acid in seed oils is a significant factor contributing to genetic and epigenetic changes.

Partially SupportedThe long-term solution for a disordered microbiome involves rectifying lifestyle factors like antibiotic use, dietary toxins, or water contaminants, not solely removing carbohydrates.

Partially SupportedCarbohydrates do not inherently cause diabetes or chronic disease; nutrient deficiency is a more significant factor.

Partially SupportedPolycyclic aromatic hydrocarbons and heterocyclic amines from cooked meat activate the Nrf2 system similarly to sulforaphane.

Partially SupportedEating steak provides the same Nrf2 system effect as eating broccoli sprouts.

Not SupportedHumic and fulvic acids are beneficial for humans, and supplements like Terra Hydrate are overhyped.

Partially SupportedA lipid panel focusing on HDL and triglycerides is sufficient for assessing lipids in metabolically healthy individuals.

Partially SupportedRestoring the microbiome long-term involves spending time in nature, consuming 'good dirt,' drinking spring water, and adopting a holistic lifestyle that includes sun exposure, adequate nutrients, and removing gut irritants like lectins.

Not SupportedSham honey, which is honey enriched with high fructose corn syrup, should be avoided.

Partially SupportedOxidative stress is a normal and vital part of human metabolism, essential for processes like insulin signaling and erythropoietin production.

Partially SupportedAncient Egyptians' primary dietary issue was likely not high carbohydrate intake, but rather a near-exclusive reliance on carbohydrates, leading to nutritional deficiencies.

Partially SupportedAncestral tubers are not starchy like modern hybridized sweet potatoes or potatoes.

Partially SupportedCarbohydrate restriction is not a long-term solution for candida; addressing gut health and repopulating the gut is necessary.

Partially SupportedPeptides are present in various animal foods including organs, bones, and colostrum.

Not SupportedCompletely eliminating all oxidative stress is undesirable and detrimental.

Partially SupportedBeta-carotene from carrots is not directly usable by the body; retinol or retinoic acid are the usable forms of vitamin A.

Partially SupportedOleic acid and linoleic acid groups did not differ with respect to any parameter measured in the study.

Not SupportedConsuming excessive amounts of antioxidants, such as turmeric to the point of turning orange, or large amounts of sulforaphane, is a bad idea because it disrupts necessary signaling pathways.

Partially SupportedInterventional studies suggest that meat is not bad for you and is beneficial, while vegetables are not a panacea, and plants contain defense chemicals.

Not SupportedDogmatic adherence to ketogenic diets and making associational errors are problematic in the health community.

Partially SupportedSpending on plant foods often results in waste, whereas meat is not wasted by humans and is evolutionarily beneficial.

Partially SupportedAn animal-based diet eliminating seed oils and focusing on meat, organs, and least toxic plant foods is recommended for sustainability in patients.

Partially SupportedStudying epigenetic changes in response to specific foods like meat, liver, rice, fruit, and honey is needed to understand their impact on gene expression.

Partially SupportedCandida often returns after carbohydrate reintroduction because the underlying gut ecosystem is not addressed.