The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
we know that heat and cold stress can induce oxidative stress in the human body we don't need sulforaphane to do this we don't need resveratrol to do this we don't need plant molecules to induce oxidative stress we do not need molecular hormetic molecules from plants but this is exactly what so for a fame is doing so for a fame is an oxidative stress just like the cold stresses
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then they go in the cold lake and it is decreased both total and oxidized are decreased after sixty minutes
suggesting that it's an automatic stressor right you're getting oxidative stress it's using up glutathione and then they get a super physiologic increase glutathione afterwards
the interventional group which does cold water swimming has baseline levels of reduced glutathione that are significantly higher than the control group and then after 60 minutes of swimming you see both of those decline and then they come back to higher than baseline
this is actually a study that shows that glutathione levels drop with whole body cold exposure and then rebound to higher than normal the next day you can see that in this graph right here initial boom 60 minutes it goes above these are cold water swimmers right here okay they have higher baseline levels of glutathione than the controls cold water swimming cold exposure is essentially doing the same thing as sulforaphane without the bad side effects
i talk about a study with cold water swimmers in berlin showing that when you go into cold water that is also an oxidative stressor that also turns on nrf2 and causes it to dissociate from keep one and increases the amount of glutathione and would then protect your dna in the same way
what happens when you swim in cold water your glutathione levels go down oxidative stress happens activating the nrf2 system and then your glutathione levels go up in the future because there is a quote-unquote hormetic effect