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Weekly · Sunday Morning

Five longevity claims.
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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Controversial Thoughts: How broccoli could be bad for you — Whalespan

Content›Video›Controversial Thoughts: How …

Controversial Thoughts: How broccoli could be bad for you

Paul Saladino17m · 2021-05-21

Claims Made

24

Claims Supported

11

Support Rate

46%

Support rate

11 of 24 claims supported

11 supported13 partial / not

Claims from this content

22

✕Not SupportedSulforaphane is directly toxic to the thyroid gland, inhibiting iodine uptake and thyroid hormone production.✓Well SupportedCold stress can induce oxidative stress in the human body, similar to molecules like sulforaphane.✓Well SupportedThe Keap1-Nrf2 mechanism recognizes molecules like sulforaphane, leading to Nrf2 migration and up-regulation of protective genes.✕Not SupportedGrains, beans, nuts, seeds, and some vegetables contain plant defense chemicals like lectins that can cause problems for humans.Well Supported

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AV

A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

NP

N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

✓

Consuming desiccated organs can provide unique nutrients that are difficult for humans to obtain otherwise.

✕Not SupportedPaul Saladino believes coffee polyphenols are not beneficial and suggests coffee may contain mold toxins, acrylamide, and pesticides.

✕Not SupportedCurcumin may have harmful effects in the human body despite potential anti-inflammatory properties.

✓Well SupportedBeneficial longevity pathways like Nrf2 and sirtuins can be activated by environmental hormetic stressors without plant molecules.

◐Partially SupportedSulforaphane is highly oxidatively active and is released when Brassica vegetables are chewed as a plant defense mechanism.

✓Well SupportedPlant defense chemicals can trigger gut inflammation, digestive issues, and autoimmune disease in some individuals.

◐Partially SupportedEnvironmental hormesis, including sunlight, exercise, ketosis, fasting, cold exposure, and heat exposure, can increase glutathione levels.

◐Partially SupportedStopping coffee consumption leads to improved sleep quality, including deeper sleep and more REM sleep, and overall feeling better for the vast majority of patients.

✕Not SupportedConsuming excessive amounts of plant compounds like sulforaphane or resveratrol can be detrimental.

◐Partially SupportedThe root cause of inflammation should be addressed rather than suppressed with anti-inflammatory supplements like turmeric.

✕Not SupportedPlants contain toxins and defense chemicals that may trigger various health issues.

◐Partially SupportedConsuming meat and organs with less toxic plant foods like fruit may lead to fewer defense chemicals and improved well-being.

◐Partially SupportedPro-oxidant plant compounds trigger the NRF2 system, upregulating endogenous antioxidant genes and protecting DNA.

◐Partially SupportedThe DNA-protective effects of compounds like sulforaphane may be context-dependent on an individual's baseline diet.

◐Partially SupportedBeneficial effects of plant compounds on DNA protection may not be observed in individuals consuming a Standard American Diet.

◐Partially SupportedThe need for plant compounds to increase glutathione and protect DNA is questionable if these benefits can be achieved through living optimally.

?Limited ResearchThe benefits of plant compounds like sulforaphane, such as turning on Nrf2 and increasing glutathione, may not offer added benefit in the context of an otherwise healthy diet and lifestyle, and may have negative side effects.

◐Partially SupportedCompounds in coffee, such as chlorogenic acid and caffeic acid, can potentially damage DNA by triggering DNA breaks.