The Keap1-Nrf2 mechanism recognizes molecules like sulforaphane, leading to Nrf2 migration and up-regulation of protective genes.

“we know this in humans that's the reason sulforaphane triggers the nrf to keep one system is because it is an oxidative it is a reactive oxidative molecule there's no question about that”

“oh these foods contain things like isothiocyanates like sulforaphane which trigger oxidative stress in the human body and and that causes this transcription factor nrf2 to translocate the nucleus and turn on a bunch of genes that turn on your antioxidant response genes”

“Sulforaphane potently activates the Nrf2 pathway, upregulating stress response genes similar to exercise and fasting.”

“But it recognizes sulforaphane or other similar molecules as they enter cells in the cytoplasm of the cells. Then there's actually a chaperone protein that's in the cytoplasm. It's called Keap1. That molecule when it binds to sulforaphane, or vice versa, changes in conformation and it releases Nrf2, which then migrates to the nucleus and turns on or up-regulates the antioxidant response element which is responsible for the transcription, for initiating transcription of a whole series of protective genes or genes in coding for a bunch of protective enzymes.”

“So, for example, I mentioned broccoli. Many of your viewers probably, if they're into health, they've probably heard of sulforaphane, which is a chemical that's in broccoli. And there's quite a bit of evidence that it can be good for health. And one of the ways is it activates antioxidant defenses in our cells. So, it's similar to exercise and fasting, which are stressors.”