Peter Attia· MD
do creatine you'd have to test it right but my recommendation I actually put out the recommendation I made a video about this I said we'll link to I said match at milligram for milligram with TMG trimethylglycine
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
do creatine you'd have to test it right but my recommendation I actually put out the recommendation I made a video about this I said we'll link to I said match at milligram for milligram with TMG trimethylglycine
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
I've been recommending this to patients for 6 months now. The big shift is patients actually do it because the explanation is concrete.
Same in nutrition counseling. The before/after framing helps.
Tracking with a CGM on top of this for 3 months. Variability dropped quickly and stayed dropped.
Worth noting the 0.71 SMD in the Kreider meta is in trained athletes. Effect in untrained adults runs closer to 0.3 — still meaningful, but the panel should reflect that gradient.
Good catch. Could the brief surface the training-status interaction inline?
How creatine affects homocysteine levels
the studies that show it does are in animals and I believe there was one human trial uh but the Mo majority shows it doesn't have any effect
the question is like maybe you need to start with a population that has elevated homoy correct yeah vegans yeah yeah yeah because it's hard it's hard to detect small changes when you already have it's easy to do you just look at some of these blood biomarkers
5 g of creatine monohydrate daily improves muscle strength and lean mass in healthy adults at standard training loads.
Creatine improves cognitive performance, especially under sleep deprivation and high cognitive load.
Creatine improves cardiovascular health markers and reduces all-cause mortality risk.
Creatine supports bone-mineral density in post-menopausal women when paired with resistance training.
Women need higher creatine doses (8–10 g/day) than men to reach the same intramuscular saturation.