And yes, the human body makes creatine from arginine and glycine along with methylation from SAMe, but the research is VERY clear that this amount is not even close to what we need to function optimally.
The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
And yes, the human body makes creatine from arginine and glycine along with methylation from SAMe, but the research is VERY clear that this amount is not even close to what we need to function optimally.
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
I've been recommending this to patients for 6 months now. The big shift is patients actually do it because the explanation is concrete.
Same in nutrition counseling. The before/after framing helps.
Tracking with a CGM on top of this for 3 months. Variability dropped quickly and stayed dropped.
Worth noting the 0.71 SMD in the Kreider meta is in trained athletes. Effect in untrained adults runs closer to 0.3 — still meaningful, but the panel should reflect that gradient.
Good catch. Could the brief surface the training-status interaction inline?
if you don't know about creatine it's made in the human body from Arginine and Glycine and then methylated with something called Sam E
we don't make enough of it to be optimal even those of us who are omnivores can benefit from creatine supplementation unless we are getting probably upwards of two pounds of meat per day for men or one and a half plus pounds of meat per day for women
if someone tells you that you can make all the creatin you need that's really clear clearly not been shown in studies no matter what you're eating most of us can benefit from supplementation with creatine but you can get enough from your diet if you are a hyper carnivore
around 50% 5 z% of the Sam the Eiden methionine generated from the methylation cycle goes to making creatine in your body
the body does make some creatine but it's only about half of what we need to be optimal so if someone tells you that you can make all the creatine you need that's really clearly not been shown in studies no matter what you're eating
but we don't make enough of it to be optimal even those of us who are omnivores can benefit from creatine supplementation unless we are getting probably upwards of two pounds of meat per day for men or one and a half plus pounds of meat per day for women
around 50% 50% of the SAM E the acidenosyl methionine generated from the methylation cycle goes to making creatine in your body
Yes, creatine is so important that your body makes it. But your body only makes a couple of grams a day. And research clearly shows that if you give it more either with a whole bunch of meat because you killed an animal and you're feasting with your tribe or some supplementation, you are going to do better.
5 g of creatine monohydrate daily improves muscle strength and lean mass in healthy adults at standard training loads.
Creatine improves cognitive performance, especially under sleep deprivation and high cognitive load.
Creatine improves cardiovascular health markers and reduces all-cause mortality risk.
Creatine supports bone-mineral density in post-menopausal women when paired with resistance training.
Women need higher creatine doses (8–10 g/day) than men to reach the same intramuscular saturation.