We can't find evidence that holds up here. Proponents are reasoning from mechanism or analogy rather than direct human data, and the most credible skeptics raise objections we can't dismiss.
many of us are using curcumin in large doses and supplementing that with piperine in a dangerous way increasing the absorption in the negative way by inhibiting UDP who can run acyl transferase and it has all these side effects
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
adding piperine to your curcumin to get 2000 x dosing is a really bad idea in my opinion because of that
if you add black pepper which is a seed which contains compounds like piperine and other toxic compounds called saffil but specifically piperine inhibits an enzyme in the liver called UDP glucuronic transferase right long name it's part of our detoxification systems and when you inhibit that enzyme with piperine and pepper you now absorb 1,000 to 2,000 times more of the circumin which is not what your body wants at all