Pharmaceutical agents for severe depression sometimes provide relief but often come with serious side effects or fail to provide relief.

“the monoamine hypothesis of depression which drove the discovery and development of all the drugs like ssris w Butrin etc those drugs often can provide support for people with depression again only 40% of people get true relief from their depression and again there are some side effect issues or major side effect issues in some cases that have to be dealt with but even the positive effects even under the best conditions oftentimes those effects don't kick in for weeks or months after somebody initiates taking the drug”