Ketamine-induced bursting patterns of electrical activity in excitatory neurons can induce long-term changes in neural circuits associated with reward, dopamine release, and mood, relieving major depression.

“those bursting patterns of electrical activity are the absolute perfect patterns of activity that induce not just short-term but long-term changes in the neural circuits associated with reward with dopamine release with disappointment and with mood in ways that are directly relevant to suppressing or providing relief from the symptoms of major depression”