Ketamine and PCP are dissociative anesthetics leveraged for the treatment of depression.

“The compounds that we're going to be talking about, you may have heard of before, one is ketamine, which is getting increasing interest in psychiatric clinics and in various experimental and clinical studies, and the other is PCP. Both ketamine and PCP are known drugs of abuse. For many years, people have abused these drugs, go by the street name, special K, et cetera. And they create dissociative anesthetic states. So dissociative states where people don't feel as closely meshed with their emotions and their perceptions. It's an odd state, I hear. And it's an odd state that clinicians are now leveraging for the treatment of depression.”