Paul Saladino· MD
so their conclusion this meta-analysis reports significantly higher concentrations of pro-inflammatory cytokines tnf alpha and il-6 in depressed subjects compared with control subjects
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
so their conclusion this meta-analysis reports significantly higher concentrations of pro-inflammatory cytokines tnf alpha and il-6 in depressed subjects compared with control subjects
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this meta-analytic result strengthens the evidence that depression is accompanied by activation of the irs which they say is the inflammatory response system
so there were significantly higher concentrations of tnf alpha the p is massively significant less than .0001 and also they go on to say that il-6 concentrations were significantly higher again the p-value is less than .0001 and depressed subjects compared with controlled subjects