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Rapamycin extends mouse lifespan 9–14%
NAD+ precursors reverse aging in humans
Blue-light glasses improve sleep quality
Walking 10 min after meals blunts glucose
Verdict change — caffeine half-life downgraded

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Does neuroinflammation trigger depression and anxiety? — Whalespan

Content›Video›Does neuroinflammation trigg…

Does neuroinflammation trigger depression and anxiety?

Paul Saladino6m · 2022-03-31

Claims Made

17

Claims Supported

15

Support Rate

88%

Support rate

15 of 17 claims supported

15 supported2 partial / not

Claims from this content

12

✓Well SupportedChronic inflammatory activation can induce brain and body changes that predispose individuals to depression.✓Well SupportedInflammation in the brain has been linked to worse outcomes in suicide, depression, and anxiety.◐Partially SupportedCSF IL-6 may play a role in the symptomatology of suicidal behavior, potentially through alterations in dopamine and serotonin metabolism.◐Partially SupportedElevated concentrations of TNF-alpha and IL-6 are significantly noted in depressed subjects relative to controls.Partially Supported

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A. Volkovreader

4h

Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.

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N. Park

2d

Would love a "what would change this verdict" RSS feed. Sign me up if it exists.

◐

The understanding of depression and anxiety is shifting from a neurotransmitter imbalance to a model involving brain inflammation.

◐Partially SupportedInflammation in the brain likely originates from inflammation in the body, potentially from the gut.

◐Partially SupportedDepression, anxiety, and eating disorders may be related to biological, neuroinflammatory causes, rather than solely neurotransmitter imbalances.

◐Partially SupportedCSF IL-6 and TNF-alpha correlated significantly with serotonin (5-HIAA) and dopamine (HVA) breakdown products, but not with MHpg.

◐Partially SupportedInflammation may cause alterations in neurotransmitters, leading to depression, psychosis, or suicidality.

◐Partially SupportedCytokines can move from the body into the brain through the blood-brain barrier.

◐Partially SupportedCytokine levels in plasma and CSF were not associated, and elevated plasma cytokine levels did not correlate with increased blood-brain barrier permeability.

◐Partially SupportedGut health is a likely source of inflammation in the body.