Chronic inflammatory activation can induce brain and body changes that predispose individuals to depression.

“and sometimes there's neuroinflammation in the brain and that can create problems with the way that that we're seeing the world which often manifests as depression in”

“i think in this case there's a pretty solid mechanistic reason to suggest that this inflammation in the brain could be a problem and could be mechanistically linked to the pathologies uh associated with depression”

“Inflammatory cytokines injected into people (ie. systemic inflammation) can cross the blood-brain barrier and cause depression.”

“Dr. Charles Raison describes the convergence of data that is directing scientists to uncover how inflammation is linked to depression.”

“Inflammatory markers, such as cytokines, are not only elevated in people with depression but may also play a causal role.”

“So it looks like there’s something about chronic inflammatory activation that induces changes in the brain and body that tee you up for depression.”

“Then when you looked at those sort of chemicals, they were actually elevated in depressed people. This was shown sort of again and again.”