Paul Saladino· MD
il-6 in the csf was significantly higher in suicide attempters than in healthy controls patients who performed violent suicide attempts displayed the highest il-6
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
il-6 in the csf was significantly higher in suicide attempters than in healthy controls patients who performed violent suicide attempts displayed the highest il-6
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so they propose a role for csf il-6 interleukin-6 a cytokine a text message sent between immune cells in the brain in the symptomatology of suicidal behavior possibly through mechanisms involving alterations of dopamine and serotonin metabolism
furthermore there was a significant positive correlation between the madras which is a measure of depression severity and the csf il6 levels in all patients