The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
it seems to me that based on the time course over which ssris work the fact that they increase serotonin uh very quickly but the relief from depression comes much later the fact that neuromodulators like serotonin are intimately involved in neuroplasticity they can some cases gate neuroplasticity that it all centers back to changing neural circuits
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
ultimately we know that depression is not a serotonin deficiency in most cases ssris or atypical anti-depressants like Ryon Wellbutrin and things of that sort when they work they probably work because of their ability to induce neuro or assist neuroplasticity right
if you change levels of neuromodulators like dopamine like serotonin you don't necessarily cure depression but you open a window for plasticity and then perhaps the therapy that you're doing can modify brain circuits more robustly